Recently a number of groups have disclosed novel compounds derived from the peptidylprolyl isomerase (PPIase) inhibition domains of the immunosuppressive drugs FK506 and rapamycin. These non-immunosuppressive small molecules, with a molecular weigh of less than 500, were found to be potent neurotrop
Current literature highlights - May 2001
- Book ID
- 104438125
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 34 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1464-3383
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โฆ Synopsis
Bone resorption inhibitors
The osteoclast vacuolar-ATPase plays an essential role in bone resorption, and inhibition of this acid pump has been shown to inhibit bone resorption both in vitro and in vivo. Inhibitors of bone resorption are potentially useful for the treatment of osteoporosis, i.e., the loss of bone (Solid phase synthesis of diamides as potential bone resorption inhibitors, K. M.
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