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Current literature highlights - August 2001

Book ID
104438134
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
35 KB
Volume
4
Category
Article
ISSN
1464-3383

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Current literature highlights - August 2
Current literature highlights - August 2002.
๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 45 KB

## Cdk4 Inhibitors Cyclins and cyclin-dependent kinases (Cdks) play important roles in regulation of the cell cycle. In particular, D-type cyclins, which are activated by rearrangement or amplification in several tumours, associate Cdk4/6. Cyclin D-Cdk4/6 complexes phosphorylate the retinoblastoma

Current literature highlights - May 2001
Current literature highlights - May 2001
๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 34 KB

## Bone resorption inhibitors The osteoclast vacuolar-ATPase plays an essential role in bone resorption, and inhibition of this acid pump has been shown to inhibit bone resorption both in vitro and in vivo. Inhibitors of bone resorption are potentially useful for the treatment of osteoporosis, i.e.

Current literature highlights - June 200
Current literature highlights - June 2001
๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 43 KB

Recently a number of groups have disclosed novel compounds derived from the peptidylprolyl isomerase (PPIase) inhibition domains of the immunosuppressive drugs FK506 and rapamycin. These non-immunosuppressive small molecules, with a molecular weigh of less than 500, were found to be potent neurotrop