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Compounds containing the phosphoramidate functionality have a range of biological activities including acting as anticancer and cardioprotective agents. As phosphoric and carboxylic equivalents, phosphoramidates have been evaluated as analogues of nucleosides and oligonucleotides. Only a limited number of nucleoside phosphoramidates have been prepared and evaluated for antiviral activity. A combinatorial approach was undertaken employing screening of biologically relevant libraries for their ability to modulate biological pathways, with or without regard to specific molecular targets. This strategy is appropriate in the context of antiviral lead discovery, simultaneously identifying leads with the potential discovery of novel molecular targets (Parallel solid-phase synthesis of nucleoside phosphoramidate libraries,
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