Autoantibodies to the thyrotropin receptor (TSHR) can act as thyrotropin agonists or antagonists, or can cause thyroid hypertrophy. Neither the autoantibody-binding sites on the TSHR nor the intracellular mechanisms by which the autoantibodies mediate their diverse functional effects are completely
Current Literature: Fas-mediated therapy for autoimmune disease.
โ Scribed by K. McCormack
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 78 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0167-5699
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Dr. St.Clair has served on the advisory boards of Genentech, Cellective Therapeutics (now owned by MedImmune), and Human Genome Sciences. Dr. Tedder has Tedder has received consulting fees (more than $10,000 per year) from Cellective Therapeutics (now owned by MedImmune), has given expert testimony
## Abstract In this review, we discuss Tโcell activation, etiology, and the current therapies of autoimmune diseases (i.e., MS, T1D, and RA). Tโcells are activated upon interaction with antigenโpresenting cells (APC) followed by a โbull's eyeโโlike formation of the immunological synapse (IS) at the