✦ LIBER ✦

Thyrotropin-receptor-mediated diseases: a paradigm for receptor autoimmunity

✍ Scribed by Bellur S. Prabhakar; Ji-Lao Fan; Gattadahalli S. Seetharamaiah

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 815 KB
Volume: 18
Category: Article
ISSN: 0167-5699
DOI: 10.1016/s0167-5699(97)01089-x

No coin nor oath required. For personal study only.

✦ Synopsis

Autoantibodies to the thyrotropin receptor (TSHR) can act as thyrotropin agonists or antagonists, or can cause thyroid hypertrophy. Neither the autoantibody-binding sites on the TSHR nor the intracellular mechanisms by which the autoantibodies mediate their diverse functional effects are completely understood. This article reviews how cloning of the TSHR has contributed to our understanding of its structure and function, and has allowed induction of experimental autoimmunity to the TSHR.

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