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Current clinical strategy for imatinib-resistant gastrointestinal stromal tumors

โœ Scribed by Masayoshi Yamamoto; Hiroyuki Konno

Book ID
107648900
Publisher
Springer Japan
Year
2009
Tongue
English
Weight
231 KB
Volume
2
Category
Article
ISSN
1865-7257

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## Abstract __BRAF__ and __NRAS__ are commonly mutated in cancer and represent the most frequent genetic events in malignant melanoma. More recently, a subset of melanomas was shown to overexpress KIT and harbor __KIT__ mutations. Although most gastrointestinal stromal tumors (GISTs) exhibit activa