Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT
β Scribed by Hyunsung Choi; Yang-Sook Chun; Yong Jae Shin; Sang Kyu Ye; Myung-Suk Kim; Jong-Wan Park
- Book ID
- 108586322
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 257 KB
- Volume
- 99
- Category
- Article
- ISSN
- 1347-9032
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We analyzed the function of a DNA domain located upstream of the cytochrome P4501A1 gene in wild-type (Hepa lclc7) mouse hepatoma cells and in high-activityvariant (HAV) cells that overtranscribe the gene in response to the inducer 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Transfection experiments
Oral doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were administered twice within 7 d (total concentration 0.01, 0.1, 1, 10, or 100 g TCDD/kg body weight) to flounder (Platichthys flesus). After 10 d of exposure, flounder were sacrificed, and the effects of TCDD exposure on hepatic microsomal