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Cultured neonatal schwann cells contain and secrete neuregulins

✍ Scribed by T.D. Raabe; D.R. Clive; T.J. Neuberger; D. Wen; G.H. De Vries

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
820 KB
Volume
46
Category
Article
ISSN
0360-4012

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✦ Synopsis

Neuregulins have become the focus of intense research due to their putative roles in the etiology of certain cancers and to their evolving roles in PNS and CNS development. Evidence has been presented that neuregulins are present in neuronal cells where they act as mediators of neuron-glial signaling. Consistent with this view, we now report that there is a dramatic differentia1 response of Schwann cells to the two major isoforms of neu differentiation factor (NDFa and NDFP). NDFP is a potent mitogen, whereas NDFa is nonmitogenic for Schwann cells. In addition, we report that Schwann cells contain endogenous NDF as well as the mRNA for both isoforms of NDF. Evidence is also presented that several isoforms of NDF are released from cultured Schwann cells. Our data suggest that in addition to functioning as a neuron-glial mediator, endogenous neuregulins may function in an autocrine/paracrine loop or in a juxtacrine-(cell-to-cell) mediated signal between individual Schwann cells or between Schwann cells and neurons.

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