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Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation

✍ Scribed by Carmen Birchmeier; Klaus-Armin Nave

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
326 KB
Volume
56
Category
Article
ISSN
0894-1491

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✦ Synopsis

Abstract

Interactions between neuronal and glial cells are crucial for establishing a functional nervous system. Many aspects of Schwann cell development and physiology are regulated by neuronal signals; possibly the most spectacular is the elaboration of the myelin sheath. An extensive line of research has revealed that one neuronal factor, termed “neuregulin”, promotes Schwann cell growth and survival, migration along the extending axon, and myelination. The versatility of glial responses elicited by this factor is thus clearly astounding. © 2008 Wiley‐Liss, Inc.

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