We report the conformational analysis by 1 H-nmr and computer simulations of five potent sweet molecules, N-(3,3-dimethylbutyl)-L-aspartyl-S-(β£-methyl)phenylalanine methylester (1; 5000 times more potent than sucrose), L-aspartyl-D-valine (S)-β£-methoxycarbonylmethylbenzylamide (2; 1400 times more po
Cultivation of taste and bounded rationality: Some computer simulations
β Scribed by Roger A. McCain
- Publisher
- Springer US
- Year
- 1995
- Tongue
- English
- Weight
- 974 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0885-2545
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A dipeptide taste ligand L-aspartyl-D-2-aminobutyric acid-(S)-alpha-ethylbenzylamide was found to be about 2000 times more potent than sucrose. To investigate the molecular basis of its potent sweet taste, we carried out conformational analysis of this molecular and several related analogues by NMR