Mutation of arginine (Arg) 143 with Ile in the monomeric mutant (Phe50Glu, Gly51Glu, Val148Lys, Ile151Lys) of copper-zinc superoxide dismutase (R143I M4SOD, where M4SOD is the above mutant) leads to a protein with low copper content. Cobalt(II) binds the demetalized protein with a low and comparable
Cu, Zn and Mn superoxide dismutases; Crystal structures, mutants, and function
โ Scribed by John A. Tainer; Hans E. Parge; Gloria E.O. Borgstahl; Cindy L. Fisher; Susan M. Redford; Darren J. Murtari; Michael J. Hickey; Duncan E. McRee; Robert A. Hallewell; Elizabeth D. Getzoff
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 97 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0162-0134
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