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Cu-Mediated Selective N-Arylation of Aminotriazole Acyclonucleosides

✍ Scribed by Wei Li; Yuting Fan; Yi Xia; Palma Rocchi; Ruizhi Zhu; Fanqi Qu; Johan Neyts; Juan L. Iovanna; Ling Peng

Publisher
John Wiley and Sons
Year
2009
Tongue
German
Weight
206 KB
Volume
92
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Novel N‐aryltriazole nucleosides were synthesized via a Cu‐mediated CN cross‐coupling reaction, using 3‐aminotriazole acyclonucleosides and various boronic acid reagents. Interestingly, N‐arylation proceeded much more rapidly on the amide group than on the amine group, leading to selective N‐arylation of the amide functionality on nucleosides containing both groups on the triazole nucleobase.

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ChemInform Abstract: Pd- and Cu-Catalyzed Selective Arylation of Benzotriazole.
✍ I. P. BELETSKAYA; D. V. DAVYDOV; M. MORENO-MANAS 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

Pd-and Cu-Catalyzed Selective Arylation of Benzotriazole. -The Pd-catalyzed reaction of benzotriazole with aryl halides is investigated. Best results are achieved under the conditions shown. The N-1 arylated benzotriazoles (III) (15 examples) are obtained in high regioselectivity. -(BELETSKAYA,