## Abstract The WNT/β‐catenin pathway is involved in numerous human cancers. Mutations of the __CTNNB1__ (β‐catenin) gene have also been detected in a subset of pediatric Wilms tumors, but the target genes of the deregulated WNT/β‐catenin pathway in these tumors have yet to be identified. To compar
CTNNB1 Mutations and Overexpression of Wnt/β-Catenin Target Genes in WT1-Mutant Wilms' Tumors
✍ Scribed by Chi-Ming Li; Connie E. Kim; Adam A. Margolin; Meirong Guo; Jimmy Zhu; Jacqueline M. Mason; Terrence W. Hensle; Vundavalli V.V.S. Murty; Paul E. Grundy; Eric R. Fearon; Vivette D'Agati; Jonathan D. Licht; Benjamin Tycko
- Book ID
- 117021558
- Publisher
- American Society for Investigative Pathology
- Year
- 2004
- Tongue
- English
- Weight
- 981 KB
- Volume
- 165
- Category
- Article
- ISSN
- 0002-9440
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Hepatoblastoma is a rare malignant tumor of the liver that occurs in children at an average age of 2 to 3 years. Epidemiologic studies have shown an increased frequency of this tumor type in families affected by adenomatous polyposis coli. In addition to the epidemiologic data, molecular genetic stu
## Abstract Wilms tumor is genetically heterogeneous, and until recently only one Wilms tumor gene was known, __WT1__ at 11p13. However, __WT1__ is altered in only ∼20% of Wilms tumors. Recently a novel gene, __WTX__ at Xq11.1, was reported to be mutated in Wilms tumors. No overlap between tumors w