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Myogenesis in Wilms’ tumor is associated with mutations of the WT1 gene and activation of Bcl-2 and the Wnt signaling pathway

✍ Scribed by Springer

Publisher
Springer
Year
2004
Tongue
English
Weight
45 KB
Volume
7
Category
Article
ISSN
1093-5266

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Mutations in the WTI tumor suppressor gene are known t o contribute t o the development of Wilms' tumor (WT) and associated gonadal abnormalities. WTI is expressed principally in the fetal kidney, developing gonads, and spleen and also in the mesothelium, which lines the coelomic cavities. These tis