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CTLA-4 in autoimmune diseases – a general susceptibility gene to autoimmunity?

✍ Scribed by Kristiansen, O P; Larsen, Z M; Pociot, F

Book ID
110037205
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
200 KB
Volume
1
Category
Article
ISSN
1466-4879

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✍ Kosh Agarwal; Albert J. Czaja; David E. Jones; Peter T. Donaldson 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 78 KB

Genetic susceptibility to type 1 autoimmune hepatitis is indicated by a preponderance of female subjects and strong associations with human leukocyte antigens (HLA) DRB1\*0301 and DRB1\*0401. The gene encoding cytotoxic T-lymphocyte antigen-4 (CTLA-4) on chromosome 2q33 may also influence autoimmuni