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CTGF enhances migration and MMP-13 up-regulation via αvβ3 integrin, FAK, ERK, and NF-κB-dependent pathway in human chondrosarcoma cells

✍ Scribed by Tzu-Wei Tan; Chih-Ho Lai; Chun-Yiu Huang; Wei-Hung Yang; Hsien-Te Chen; Horng-Chaung Hsu; Yi-Chin Fong; Chih-Hsin Tang


Book ID
118284202
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
493 KB
Volume
107
Category
Article
ISSN
0730-2312

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## Abstract Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Osteopontin (OPN), which abundantly expressed in bone matrix, is involved in cell adhesion, migration, invasion and proliferation via interaction with its receptor, that is, α