α-Mangostin Suppresses Phorbol 12-myristate 13-acetate-Induced MMP-2/MMP-9 Expressions via αvβ3 Integrin/FAK/ERK and NF-κB Signaling Pathway in Human Lung Adenocarcinoma A549 Cells

Osteopontin increases migration and MMP-

Osteopontin increases migration and MMP-9 up-regulation via αvβ3 integrin, FAK, ERK, and NF-κB-dependent pathway in human chondrosarcoma cells

✍ Ying-Ju Chen; Ying-Ying Wei; Hsien-Te Chen; Yi-Chin Fong; Chin-Jung Hsu; Chun-Ha 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 361 KB

## Abstract Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Osteopontin (OPN), which abundantly expressed in bone matrix, is involved in cell adhesion, migration, invasion and proliferation via interaction with its receptor, that is, α