Crystallographic Analysis of Anti-p24 (HIV-1) Monoclonal Antibody Cross-Reactivity and Polyspecificity
โ Scribed by Thomas Keitel; Achim Kramer; Helga Wessner; Christa Scholz; Jens Schneider-Mergener; Wolfgang Hohne
- Book ID
- 117267414
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 749 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0092-8674
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## Abstract Murine monoclonal antibodies (Mabs) to the major core protein p24 of the human immunodeficiency virus type 1 (HIVโ1) were tested for their ability to inhibit the replication and spread __of__ the virus in permanent cell cultures (Molt4/8, K37, H9) and in the culture of 11โ2 stimulated T
## Abstract The binding of four epitopeโrelated peptides and three libraryโderived, epitopeโunrelated peptides of different lengths (10โ14 amino acids) and sequence by antiโp24 (HIVโ1) monoclonal antibody CB4โ1 and its Fab fragment was studied by isothermal titration calorimetry. The binding consta