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Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes

✍ Scribed by Huai, Qing; Zhou, Aiwu; Lin, Lin; Mazar, Andrew P; Parry, Graham C; Callahan, Jennifer; Shaw, David E; Furie, Bruce; Furie, Barbara C; Huang, Mingdong

Book ID
109965528
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
331 KB
Volume
15
Category
Article
ISSN
1545-9993

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Urokinase-type plasminogen activator (urokinase, uPA) and its receptor, uPAR, have been implicated in cell adhesion, migration, tissue remodelling and tumour-cell invasion. uPAR has three domains and is anchored to membranes by a glycosyl-phosphatidylinositol (GPI) anchor. Recombinant uPAR without i