Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere
✍ Scribed by Liang Tong; Susan Pav; Suet Mui; Daniel Lamarre; Christiane Yoakim; Pierre Beaulieu; Paul C Anderson
- Book ID
- 114328847
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 834 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0969-2126
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Peptidomimetic inhibitors of human immunodeficiency virus-1 protease are successful lead substances for the development of virostatic drugs against HIV as the causative agent of acquired immunodeficiency syndrome (AIDS). The hydroxyethylamine isostere of the proteolytic cleavage intermediate provide
The structure of a complex between a hexapeptide-based inhibitor, MVT-101, and the chemically synthesized (Aba 67,95,167,195; Aba: L-a-amino-n-butyric acid) protease from the human immunodeficiency virus (HIV-1), reported previously at 2.3 Å has now been refined to a crystallographic R factor of 15.