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Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation

✍ Scribed by Jeffrey H. Till; Manuel Becerra; Anke Watty; Yun Lu; Yuliang Ma; Thomas A. Neubert; Steven J. Burden; Stevan R. Hubbard


Book ID
114329139
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
398 KB
Volume
10
Category
Article
ISSN
0969-2126

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✍ Andreas Kuglstatter; April Wong; Stan Tsing; Simon W. Lee; Yan Lou; Armando G. V πŸ“‚ Article πŸ“… 2011 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 463 KB

## Abstract Bruton's tyrosine kinase (BTK) plays a key role in B cell receptor signaling and is considered a promising drug target for lymphoma and inflammatory diseases. We have determined the X‐ray crystal structures of BTK kinase domain in complex with six inhibitors from distinct chemical class