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Insights into autoregulation from the crystal structure of twitchin kinase

✍ Scribed by Hu, Shu-Hong; Parker, Michael W.; Yi Lei, Jun; Wilce, Matthew C. J.; Benian, Guy M.; Kemp, Bruce E.


Book ID
109788864
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
566 KB
Volume
369
Category
Article
ISSN
0028-0836

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✍ Andreas Kuglstatter; April Wong; Stan Tsing; Simon W. Lee; Yan Lou; Armando G. V πŸ“‚ Article πŸ“… 2011 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 463 KB

## Abstract Bruton's tyrosine kinase (BTK) plays a key role in B cell receptor signaling and is considered a promising drug target for lymphoma and inflammatory diseases. We have determined the X‐ray crystal structures of BTK kinase domain in complex with six inhibitors from distinct chemical class