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Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase

✍ Scribed by Jacobs, Steven A; Podell, Elaine R; Cech, Thomas R

Book ID
109966436
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
775 KB
Volume
13
Category
Article
ISSN
1545-9993

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Reverse transcriptase (RT) is a modular enzyme carrying polymerase and ribonuclease H (RNase H) activities in separable domains. Retroviral replication requires both of these activities. The RNase H domain is responsible for hydrolysis of the RNA portion of RNAβ€’DNA hybrids, and this activity require