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Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors

✍ Scribed by Xiayang Qiu; Cheryl A. Janson; Ward W. Smith; Susan M. Green; Patrick McDevitt; Kyung Johanson; Paul Carter; Martin Hibbs; Ceri Lewis; Alison Chalker; Andrew Fosberry; Judith Lalonde; John Berge; Pamela Brown; Catherine S.V. Houge-Frydrych; Richard L. Jarvest


Book ID
111753256
Publisher
Cold Spring Harbor Laboratory Press
Year
2001
Tongue
English
Weight
488 KB
Volume
10
Category
Article
ISSN
0961-8368

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## Abstract The crystal structure of Phenylalanyl‐tRNA synthetase from __E. coli__ (__Ec__PheRS), a class II aminoacyl‐tRNA synthetase, complexed with phenylalanine and AMP was determined at 3.05 Γ… resolution. __Ec__PheRS is a (Ξ±Ξ²)~2~ heterotetramer: the Ξ±Ξ² heterodimer of __Ec__PheRS consists of 11