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Crystal structure of N-acetylgalactosamine-6-sulfatase: The molecular basis for Mucopolysaccharidosis IVA

✍ Scribed by Rivera-Colon, Yadilette; Schutsky, Emily K.; Garman, Scott C.


Book ID
123465559
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
87 KB
Volume
108
Category
Article
ISSN
1096-7192

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Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS; EC 3.1.6.4). The deficiency of N-acetylgalactosamine-6-sulfate sulfatase leads to lysosomal accumulation of undegraded glycosaminoglycans, keratan sulfate