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Crystal Structure of N-Acetylgalactosamine-6-Sulfatase: The Molecular Basis for Mucopolysaccharidosis Iva

✍ Scribed by Rivera-Colon, Yadilette; Schutsky, Emily K.; Garman, Scott C.


Book ID
122299872
Publisher
Biophysical Society
Year
2013
Tongue
English
Weight
52 KB
Volume
104
Category
Article
ISSN
0006-3495

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Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS; EC 3.1.6.4). The deficiency of N-acetylgalactosamine-6-sulfate sulfatase leads to lysosomal accumulation of undegraded glycosaminoglycans, keratan sulfate