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Crystal structure of human MTH1 and the 8-oxo-dGMP product complex

✍ Scribed by Linda M. Svensson; Ann-Sofie Jemth; Matthieu Desroses; Olga Loseva; Thomas Helleday; Martin Högbom; Pål Stenmark


Book ID
113622671
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
736 KB
Volume
585
Category
Article
ISSN
0014-5793

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✍ M.A. Massiah; V. Saraswat; H.F. Azurmendi; A.S. Mildvan 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 335 KB

The MutT pyrophosphohydrolase from E. coli (129 residues) catalyzes the hydrolysis of nucleoside triphosphates (NTP), including 8-oxo-dGTP, by substitution at Pb, to yield NMP and pyrophosphate. The product, 8-oxo-dGMP is an unusually tight binding, slowly exchanging inhibitor with a K D ¼ 52 nM, (D