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Crystal, solution, and molecular modeling structural properties and muscarinic antagonist activity of azaprophen

✍ Scribed by Carroll, F. Ivy; Abraham, Philip; Mascarella, S. Wayne; Singh, P.; Moreland, Charles G.; Sankar, S. S.; Kwon, Yong Wha; Triggle, David J.


Book ID
126081888
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
692 KB
Volume
34
Category
Article
ISSN
0022-2623

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In an attempt to develop more selective muscarinic acetylcholine receptor (m-AcChR) antagonists, (R)-1-azabicyclo[2.2.2]oct-3-yl-thioxanthene-9-carboxylate, (R,S)-thiochromane-4-carboxylate, and (R,S)-chromane-4-carboxylate were synthesized. Evaluation of the binding affinities of these compounds to