## Abstract The melanocortin receptors are involved in many physiological functions, including pigmentation, sexual function, feeding behavior, and energy homeostasis, making them potential targets for drugs to treat obesity, sexual dysfunction, etc. Understanding the conformational basis of the re
Solution structures and molecular interactions of selective melanocortin receptor antagonists
β Scribed by Chul-Jin Lee; Ji-Hye Yun; Sung-Kil Lim; Weontae Lee
- Publisher
- Korean Society for Molecular and Cellular Biology
- Year
- 2010
- Tongue
- English
- Weight
- 1006 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1016-8478
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Selective and potent antagonists for the A 2A adenosine receptors have been described recently. The most potent compounds have a triazolo-pyrimidine structure, whereas 8-styryl-xanthines usually possess lower affinity at the A 2A receptor. We have examined the quantitative structure activity relatio