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Cryopreserved Porcine Hepatocytes: Expression and Induction of Cytochrome P450, Isoform CYP2E1

✍ Scribed by E. Baldini; R. Cursio; G. DeSousa; A. Margara; J. Honiger; M.-C. Saint-Paul; P. Bayer; V. Raimondi; R. Rahmani; J. Mouiel; J. Gugenheim

Book ID: 116935163
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 230 KB
Volume: 41
Category: Article
ISSN: 0041-1345
DOI: 10.1016/j.transproceed.2009.02.061

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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to