Crossreactivity of the T-cell receptor

✍ Scribed by José A.M. Borghans; Rob J. De Boer

• Book ID: 104298957
• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 91 KB
• Volume: 19
• Category: Article
• ISSN: 0167-5699
• DOI: 10.1016/s0167-5699(98)01317-6

✦ Synopsis

orchestrate the production of NO in a major way.

When clearing occurs in psoriasis using a systemic drug 4 , the lesions become less erythematous and clear from the inside out (V.B. Morhenn, unpublished). In regard to the immunostaining of inducible nitric oxide synthase (iNOS) in psoriatic lesions, clearly the labeling is associated with epidermal cells 5 . Unfortunately, double staining to differentiate LCs from KCs was not performed in this study, however, the results suggest that LCs are also stained! Readiness to deal with wounds may explain the prevalence (~2%) of the 'psoriatic gene' in the American population. This frequency of the abnormal gene suggests that harboring it has survival value -psoriatic skin appears primed and ready to go if a bacterial infection occurs or a defect in the epidermis needs to be healed.