Crossreaction of monoclonal Anti-T-cell antibodies: Implications for classifying B-cell leukemias

✍ Scribed by Munker, R. ;Thiel, E. ;Kummer, U. ;Rodt, H. ;Thierfelder, S.

• Publisher: Springer-Verlag
• Year: 1983
• Weight: 348 KB
• Volume: 46
• Category: Article
• ISSN: 1432-0584
• DOI: 10.1007/bf00320665

✦ Synopsis

Cell samples from 62 patients with B-cell leukemias (33 CLL, 8 IC, 6 PLL, 4 HCL, 2 ALL and 9 other NHL) were tested with a series of monoclonal antibodies (A50, T101, Lyt2, Leu 1, M203) directed against T cells and shown to crossreact with B-CLL. The results demonstrate a heterogeneity of B-cell leukemias as all typical cases of CLL were reactive whereas most other cases were negative. Using the fluorescence-activated cell sorter, a somewhat stronger reaction was seen in early or benign cases of CLL, compared to advanced cases. All B-cell leukemias tested expressed the Ia antigen.