✦ LIBER ✦

Crossover Designs with Random Periods

✍ Scribed by Prof. Dr. P. Roebruck

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 386 KB
Volume: 33
Category: Article
ISSN: 0323-3847
DOI: 10.1002/bimj.4710330403

No coin nor oath required. For personal study only.

✦ Synopsis

Crossover experiments usually are modelled with fixed treatment, carryover. and period effects while the effecta of subjects are assumed to be random. In actual realisations of crossover experiments however periods are quite arbitrary intervals of time, depending on administrative affairs for instance and possibly they are even varying front subject to subject. Modelling these arbitrary periods as random effectseither globally for d l subjects or individually for each one seems to be more adequate than theassumption of fixed period effects. This pnper is concerned with the two treatments, two periods crossover design. It is described that-in spite of the somewhat involved covariance structure-the estimators and tests developed for models with fixed period effects remain valid for models with random effects for periods provided that no treatmentxperiod interaction exists.

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