Crossing over and chromosome 21 nondisjunction: A study of 60 families
โ Scribed by Perroni, L. ;Bricarelli, F. Dagna ;Grasso, M. ;Pierluigi, M. ;Baldi, M. ;Pedemonte, C. ;Strigini, P.
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 730 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0148-7299
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Chromosome analysis of a newborn boy with Down syndrome resulted in the identification of a family with an unusual derivative chromosome 22. The child has 46 chromosomes, including two chromosomes 21, one normal chromosome 22, and a derivative chromosome 22. Giemsa banding and fluorescent in situ hy
We analyzed the possibility of inherited predisposition to nondisjunction in a family with two cases of Down syndrome using restriction fragment length polymorphisms and cytogenetic heteromorphisms. In both patients the extra chromosome 21 was the result of a nondisjunction event at first meiotic di