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Study of the origin of nondisjunction in a family with two cases of Down syndrome using cytogenetic and molecular polymorphisms

✍ Scribed by Stinissen, Piet ;Van Roy, Bernadette ;Van Camp, Guy ;Backhovens, Hubert ;Partoens, Peter ;Wehnert, Anita ;Verniers, Heidi ;Dumon, Jan ;Vandenberghe, Antoon ;Van Broeckhoven, Christine

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 400 KB
Volume: 37
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320370727

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✦ Synopsis

We analyzed the possibility of inherited predisposition to nondisjunction in a family with two cases of Down syndrome using restriction fragment length polymorphisms and cytogenetic heteromorphisms. In both patients the extra chromosome 21 was the result of a nondisjunction event at first meiotic division in the mother. Since both patients are maternally related, genetic predisposition cannot be excluded in this family.

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