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Cross talk of dual-signal transduction systems in the regulation of DNA synthesis by parathyroid hormone in osteoblastic osteosarcoma cells

✍ Scribed by Junichi Kano; Toshitsugu Sugimoto; Masaaki Fukase; Kazuo Chihara

Book ID
112119049
Publisher
American Society for Bone and Mineral Research
Year
2009
Tongue
English
Weight
592 KB
Volume
8
Category
Article
ISSN
0884-0431

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Cross-talk of parathyroid hormone-respon
Cross-talk of parathyroid hormone-responsive dual signal transduction systems in osteoblastic osteosarcoma cells: Its role in PTH-induced homologous desensitization of intracellular calcium response
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The present study was designed to characterize the cross-talk of parathyroid hormone (PTH)-responsive dual signal transduction systems (CAMP-dependent protein kinase (PKA) and calcium/protein kinase C [PKCI) and its participation in PTH-induced homologous desensitization of intracellular calcium ([C

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Second messenger signaling in the regulation of cytosolic pH and DNA synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: Role of Na+/H+ exchange
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## Abstract The present study was performed to investigate the regulation of cytosolic pH (pHi) and DNA synthesis by parathyroid hormone(PTH) and PTH‐related peptide (PTHrP) in osteoblasts, using osteoblastic osteosarcoma cells, UMR‐106 which possessed PTH‐responsive dual signal transduction system