Cross-sectional and longitudinal analysis of myelin-reactive T cells in patients with multiple sclerosis
✍ Scribed by Jan D. Lünemann*; Sandra Rückert*; Florian Kern; Uwe Wendling; Ruud van der Zee; Hans D. Volk; Frauke Zipp
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 548 KB
- Volume
- 251
- Category
- Article
- ISSN
- 0340-5354
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## Abstract While it is widely accepted that myelin reactive T cells are key players in the immunopathogenesis of multiple sclerosis (MS), the initial triggers that turn on these self‐reactive T‐cells remain to be determined. One mechanism, which is already text book knowledge for a decade, is mole
Several reports have suggested an association of human herpesvirus 6 (HHV-6) with multiple sclerosis. Autoreactive T lymphocytes directed against myelin components seem to contribute to the pathogenesis of the disease. It has been suggested that molecular mimicry between viral and self-antigens migh