✦ LIBER ✦

Critical role of IL-2 and TGF-β in generation, function and stabilization of Foxp3+CD4+ Treg

✍ Scribed by David A. Horwitz; Song Guo Zheng; Juhua Wang; J. Dixon Gray

Book ID: 102168828
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 108 KB
Volume: 38
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.200738109

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✦ Synopsis

Abstract

CD4^+^Foxp3^+^ Treg consist of two indistinguishable subsets induced in either the thymus or the periphery. In addition to their suppressive activities, IL‐6 can convert natural Treg to pro‐inflammatory IL‐17‐producing cells, but those induced with IL‐2 and TGF‐β remain Treg. Unlike mouse CD4^+^CD25^–^ cells, which rapidly become polyclonal Foxp3^+^CD25^+^ Treg when activated appropriately with IL‐2 and TGF‐β, human T cells require multiple stimulations to become similar suppressor cells.

See accompanying commentary: http://dx.doi.org/10.1002/eji.200738111

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