✦ LIBER ✦

Critical Flicker Fusion Threshold in patients with Alzheimer's disease and vascular dementia

✍ Scribed by Stephen Curran; Simon Wilson; Shabir Musa; John Wattis

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 80 KB
Volume: 19
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.1134

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Critical Flicker Fusion Threshold (CFFT) is a psychophysical threshold and in psychological terms is regarded as a measure of information processing capacity. The test has previously been shown to be a valid and reliable measure of CNS functioning in patients with Alzheimer's disease and may be a useful as a screening measure for the early detection of Alzheimer's disease (AD).

Methods

Consecutive referrals to the Wakefield Memory Clinic who met DSM‐IV criteria for AD or vascular dementia (VaD) were invited to take part in the study. A range of neuropsychological tests and CFFT were administered to the two groups using standardised protocols and the ability of these various tests to distinguish between the two conditions was investigated.

Results

Forty‐six patients were included in the study. Of the various tests, only the descending component of CFFT and word fluency were significantly different in the two groups. In addition, the descending threshold had a sensitivity of 83% and a specificity of 69%.

Conclusion

CFFT could be useful as a screening instrument for early AD when combined with other measures and could facilitate the decision to commence antidementia treatment at an early stage. Further longitudinal work is needed to establish this. Copyright © 2004 John Wiley & Sons, Ltd.

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