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Cremophor EL causes (pseudo-) non-linear pharmacokinetics of paclitaxel in patients

โœ Scribed by Tellingen, O van; Huizing, M T; Panday, V R Nannan; Schellens, J H M; Nooijen, W J; Beijnen, J H


Book ID
110002479
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
81 KB
Volume
81
Category
Article
ISSN
0007-0920

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Differential activity of cremophor EL an
โœ Katalin Csรณka; Sumeer Dhar; Helena Fridborg; Rolf Larsson; Peter Nygren ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 144 KB ๐Ÿ‘ 2 views

## Background: Previous studies indicate that cremophor el (cel), the excipient for taxol, a clinical preparation of paclitaxel, has biologic properties per se. ## Methods: The cytotoxic activity of taxol and its solvents cel/ethanol, paclitaxel in ethanol, and 14 other cytotoxic drugs was invest