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CREM, a master-switch of the transcriptional cascade in male germ cells

โœ Scribed by Cesare, D.; Fimia, G. M.; Sassone-Corsi, P.

Book ID
125334714
Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
93 KB
Volume
23
Category
Article
ISSN
0391-4097

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โœ Paolo Sassone-Corsi ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 38 KB ๐Ÿ‘ 1 views

Cyclic AMP-responsive element modulator (CREM) is a transcription factor highly expressed in the post-meiotic germ cells of the testis. Its pivotal role is to regulate the expression of several germ cell-specific genes, a crucial function as demonstrated by the severe phenotype of mice whose CREM ge