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CpG Methylation Inactivates the Transcriptional Activity of the Promoter of the Humanp53Tumor Suppressor Gene

✍ Scribed by Maria Schroeder; Marc J. Mass

Book ID
115580402
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
149 KB
Volume
235
Category
Article
ISSN
0006-291X

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## Abstract Retinoic acid receptor B2 (__RARB2__) is frequently inactivated in cancer. Methylation in the 5′‐untranslated region and first exon is known to play a role; however, few studies have analyzed the detailed methylation pattern of the promoter region. We show that hypo‐ and hypermethylated