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CpG island methylation and expression of tumour-associated genes in lung carcinoma

โœ Scribed by Reinhard Dammann; Maria Strunnikova; Undraga Schagdarsurengin; Matthias Rastetter; Mirko Papritz; Uwe E. Hattenhorst; Hans-Stefan Hofmann; Rolf-Edgar Silber; Stefan Burdach; Gesine Hansen


Book ID
116428522
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
584 KB
Volume
41
Category
Article
ISSN
0959-8049

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## Abstract Previous studies on esophageal squamous cell carcinoma (ESCC) indicated that it contains much dysregulation of microRNAs (miRNAs). DNA hypermethylation in the miRNA 5โ€ฒ regulatory region is a mechanism that can account for the downregulation of miRNA in tumors (Esteller, N Engl J Med 200