## Abstract To clarify the significance of p73 in EpsteinโBarr virus (EBV)โassociated gastric carcinoma (GC), the immunohistochemical expression and CpGโisland methylation of p73 were evaluated in cancer tissues and adjacent nonneoplastic tissues of GC with and without EBV infection. Loss of p73 ex
Global and non-random CpG-island methylation in gastric carcinoma associated with Epstein-Barr virus
โ Scribed by Ja-Mun Chong; Kazuya Sakuma; Makoto Sudo; Tetsuo Ushiku; Hiroshi Uozaki; Junji Shibahara; Hideo Nagai; Nobuaki Funata; Hirokazu Taniguchi; Hiroyuki Aburatani; Masashi Fukayama
- Book ID
- 108582198
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 184 KB
- Volume
- 94
- Category
- Article
- ISSN
- 1347-9032
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๐ SIMILAR VOLUMES
## Abstract Promoter hypermethylation of various tumorโrelated genes is extremely frequent in gastric carcinoma (GC) associated with EpsteinโBarr virus (EBV). To investigate the significance of the promoter methylation in this type of GC, we examined the methylation densities of the promoter region
## BACKGROUND. Gastric carcinoma with lymphoid stroma (GCLS), known to have a more favorable prognosis than ordinary gastric carcinoma, has been suggested to be closely associated with the Epstein-Barr virus (ERV). However, there are many clinicopathologic problems that remain unsolved.
In order to understand the character of Epstein-Barr virus (EBV)-associated gastric carcinoma with lymphoid stroma (GCLS), we examined cell proliferation and death in comparison with gastric carcinoma without prominent lymphoid stroma (conventional gastric carcinoma). The EBV-encoded small RNA I (EB