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COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast, and is a target for treatment

✍ Scribed by Generali, D; Buffa, F M; Deb, S; Cummings, M; Reid, L E; Taylor, M; Andreis, D; Allevi, G; Ferrero, G; Byrne, D; Martinotti, M; Bottini, A; Harris, A L; Lakhani, S R; Fox, S B


Book ID
127186283
Publisher
Nature Publishing Group
Year
2014
Tongue
English
Weight
604 KB
Volume
111
Category
Article
ISSN
0007-0920

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Elevated expression of cyclooxygenase-2
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## Abstract ## BACKGROUND Cyclooxygenases regulate the production of prostaglandins and play a role in tumor development and progression. The authors investigated the prognostic impact of expression of the cyclooxygenase (COX) isoforms, COX‐1 and COX‐2, on disease‐free survival and progression‐fre