Cover Picture: Substrates for Investigation of DNA Polymerase Function: Synthesis and Properties of 4′-C-Alkylated Oligonucleotides (Eur. J. Org. Chem. 10/2003)

✍ Scribed by Ilka Detmer; Daniel Summerer; Andreas Marx

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 75 KB
• Volume: 2003
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200390221

✦ Synopsis

Abstract

The cover picture shows the design and structures of 4′‐C‐alkylated thymidines. These modified nucleosides were synthesized and subsequently incorporated into oligonucleotides to probe inherent properties of the DNA double helix (left‐hand) side) and DNA polymerases in their interplay with their DNA substrates (right‐hand side). Details are discussed in the article by I. Detmer, D. Summerer and A. Marx on p. 1837 ff.