Cover Picture: Structure–Activity Relationship Analysis of the Peptide Deformylase Inhibitor 5-Bromo-1H-indole-3-acetohydroxamic Acid (ChemMedChem 2/2009)

✍ Scribed by Sylvain Petit; Yann Duroc; Valéry Larue; Carmela Giglione; Carole Léon; Coralie Soulama; Alexis Denis; Frédéric Dardel; Thierry Meinnel; Isabelle Artaud

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 694 KB
• Volume: 4
• Category: Article
• ISSN: 1860-7179
• DOI: 10.1002/cmdc.200990004

✦ Synopsis

Abstract

The cover picture shows a “reverse” indole derivative in complex with Bacillus stearothermophilus peptide deformylase (PDF). This compound was selected from a structure–activity relationship study as a potent inhibitor of bacterial PDFs and shows antibacterial activity toward Bacillus subtilis as well as other pathogens such as Streptococcus pneumoniae and Staphylococcus aureus. For more details, see the Full Paper by I. Artaud et al. on p. 261 ff.magnified image