Cover Picture: Interaction of Artemisinins with Oxyhemoglobin Hb–FeII, Hb–FeII, CarboxyHb–FeII, Heme–FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria (ChemMedChem 12/2009)

✍ Scribed by Paolo Coghi; Nicoletta Basilico; Donatella Taramelli; Wing-Chi Chan; Richard K. Haynes; Diego Monti

• Book ID: 102806206
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 835 KB
• Volume: 4
• Category: Article
• ISSN: 1860-7179
• DOI: 10.1002/cmdc.200990056

✦ Synopsis

The cover picture shows erythrocytes infected with malaria parasites after Giemsa staining (background). Heme, either within the hemoglobin (Hb) (ribbon diagram) or produced by catabolism of the Hb by the parasite, is considered to be responsible for the antimalarial activity of artemisinins (general structure shown). This hypothesis is examined more closely by use of carbon monoxide to passivate the Hb-iron complex. For more details, see the Full Paper by R. K. Haynes and D. Monti et al. on p. 2045 ff.