Cover Picture: ChemBioChem 12/2002

✍ Scribed by Björn Holm; Johan Bäcklund; Miguel A. F. Recio; Rikard Holmdahl; Jan Kihlberg

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 46 KB
• Volume: 3
• Category: Article
• ISSN: 1439-4227
• DOI: 10.1002/1439-7633(20021202)3:12<1163::aid-cbic1163>3.0.co;2-u

✦ Synopsis

The cover picture shows a schematic representation of how collagen-induced arthritis, a model for rheumatoid arthritis, is induced in mice by immunization with type II collagen. Immunization leads to presentation of glycopeptide antigens by major histocompatibility complex (MHC) molecules to T cells. By using a panel of synthetic glycopeptides, the T cells were found to recognize the galactose moiety attached to hydroxylysine 264 in the type II collagen fragment CII256-270. These results, and knowledge of which amino acids anchor CII256-270 in the cleft of the class II MHC molecule, were used to generate the structural model of the glycopeptide±MHC complex also shown in the cover picture. Further details can be found in the article by Kihlberg and co-workers on p. 1209 ff. (We thank Bjˆrn Holm and Andreas Larsson for assistance in the preparation of the cover picture.