✦ LIBER ✦

Cover Picture: Autoreactive B cells get activated in extrafollicular sites – Eur. J. Immunol. 12/2007

✍ Scribed by Florian Weisel; Ute Wellmann; Thomas H. Winkler

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 494 KB
Volume: 37
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.200790058

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The cover image schematically depicts the mechanisms proposed by Winkler and colleagues (pp. 3330–3333) as underlying the extrafollicular activation of rheumatoid factor B cells by chromatin–immune complexes. The follicular region is shown in orange, the marginal sinus in green, the marginal zone in turquoise, and the red pulp in red. The scheme is based on the data obtained by Shlomchik and colleagues (pp. 3339–3351) in their new mouse model of extrafollicular somatic hypermutation, a characteristic of murine lupus. The model importantly uses IgG anti‐chromatin antibodies rather than conventional immune complexes.

📜 SIMILAR VOLUMES

Cover Picture: Expansion and activation

Cover Picture: Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection – Eur. J. Immunol. 7/2007

✍ Constance A. M. Finney; Matthew D. Taylor; Mark S. Wilson; Rick M. Maizels 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 616 KB

## Abstract The cover shows a photograph of an individual adult __Heligmosomoides polygyrus__, a gastrointestinal nematode parasite and was provided by Finney __et al.__ (__pp.__ 1874–1886). In this study authors analyse in detail the development and phenotype (CTLA‐4, GITR, CD103) of cells respons